Disable

Remove the grayed out machines from Acronis Management Server and then add them back to solve the issue

The "Manage this machine" button is grayed out when connected to the Acronis Management Console machine via RDP. This is normal behavior

The issue is with the User Account Control turned on

Provide the username in the form of DOMAIN\Username; make sure the user is a member of Administrators group, Domain Admins group, Enterprise Admins group; delete the v8.0 subkey from Windows Registry

How to disable Windows shell extensions that show up in the context menu after installation of Acronis True Image

The serial key you are attempting to enter is incorrect

Issue is fixed in Acronis Backup 11.5 (Acronis Backup & Recovery 11.5). Upgrade or remove the space gap.

Launching Acronis Backup & Recovery 11 Standalone or pressing "Manage this machine" button asks for credentials when connected to the machine via RDP. This is normal behavior

There are either not enough rights to back up the remote machine, or Acronis Agent serial key did not register properly

There is no progress bar shown on a disabling or enabling operation

Introduction

This article explains how to temporarily turn off Windows Defender Antivirus in case it conflicts with Acronis software on Windows 10, e.g. prevents successful software installation or update/upgrade.