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Acronis Nonstop Backup and defragmentation are fully compatible and do not interfere
On the first reboot after defragmentation there is a black screen showing "Non-system disk, press any key"
Incremental or differential backups are larger when performed after disk defragmentation or full restore. This can also happen with Acronis True Image Home 2009, or if there is a .pst file and the backup method is "fast incremental"